hedgehog pathway inhibitor — TargetMol Chemicals

Cat No.	Product Name	Synonyms	Targets
T3156	Ciliobrevin A	Hedgehog Pathway Inhibitor 4,HPI-4	Hedgehog/Smoothened
	Ciliobrevin A (HPI-4) is an inhibitor of hedgehog signaling pathway with an IC50 <10 μM.		Hedgehog/Smoothened
T3912	Saikosaponin B1		Others
	Saponin activator. Activates release of Prostaglandin E2 in vitro. Anti-inflammatory agent. Orally active. Active in vivo and in vitro.		Others
T20723	LGE-899	Sonidegib metabolite M48,LGE 899	Drug Metabolite
	LGE-899 (Sonidegib metabolite M48) is a main metabolite of Sonidegib which is an inhibitor of the hedgehog pathway. The Tmax of LGE-899(60 h) is much longer than Sonidegib.		Drug Metabolite
T3588	JK184		Hedgehog/Smoothened
	JK184 is a potent Hedgehog (Hh) pathway inhibitor.		Hedgehog/Smoothened
T15019	CUR61414		Hedgehog/Smoothened
	CUR61414 is a cell-permeable inhibitor of Hedgehog signaling pathway (IC50 =100-200 nM) and selectively binds to smoothened (Ki = 44 nM).		Hedgehog/Smoothened
T22089	HPI 1		Hedgehog/Smoothened
	HPI 1 is a hedgehog (Hh) signaling inhibitor. Inhibits Sonic hedgehog (Shh)-, SAG- and Gli-induced Hh pathway activation in Shh-LIGHT2 cells (IC50 values are 1.5, 1.5, 4, and 6 μM for Shh-, SAG-, Gli2- and Gli1-induced a...		Hedgehog/Smoothened
T3460	HhAntag		Hedgehog/Smoothened , Smo
	HhAntag is a small molecule inhibitor of GLI1-mediated transcription, an essential down-stream element of the Hedgehog (Hh) pathway with the anti-tumor activity.		Hedgehog/Smoothened , Smo
T2590	Vismodegib	Erivedge,GDC-0449,RG 3616	Hedgehog/Smoothened , ABC , Autophagy
	Vismodegib (GDC-0449) is a hedgehog pathway inhibitor (IC50: 3 nM). It also inhibits P-gp (IC50: 3.0 μM), ABCG2 (IC50: 1.4 μM).		Hedgehog/Smoothened , ABC , Autophagy
T6891	MK-4101		Apoptosis , Hedgehog/Smoothened , Smo
	MK-4101, an effective inhibitor of the Hedgehog pathway, has anti-tumor activity through the induction of extensive apoptosis and inhibition of proliferation in tumor cells.		Apoptosis , Hedgehog/Smoothened , Smo
T15019L	CUR61414 hydrochloride	CUR61414 hydrochloride (334998-36-6 Free base)	Hedgehog/Smoothened
	CUR61414 hydrochloride is a potent and cell permeable inhibitor of Hedgehog signaling pathway (IC50 =100-200 nM). CUR61414 hydrochloride is a small-molecule aminoproline class compound. CUR61414 hydrochloride selectively...		Hedgehog/Smoothened
T12797	RU-SKI 43	RUSKI 43	Hedgehog/Smoothened , Acyltransferase
	RU-SKI 43 is a potent and selective hedgehog acyltransferase (Hhat) inhibitor with an IC50 of 850 nM.RU-SKI 43 has anticancer activity and is a potential compound for the treatment of lung adenocarcinomas.RU-SKI 43 reduc...		Hedgehog/Smoothened , Acyltransferase
T5465	PF-5274857	PF-5274857 freebase	Smo
	PF-5274857 (PF-5274857 free base) is an effective and selective hedgehog signaling pathway inhibitor (IC50: 5.8 nM and a Ki: 4.6 nM). PF-5274857 is a potentially attractive clinical candidate for the treatment of tumor t...		Smo
T71299	M-25
	M-25 is a Smoothened antagonist and inhibitor of the Hedgehog pathway.
T71455	Glasdegib hydrochloride
	Glasdegib hydrochloride is a small-molecule inhibitor of the Hedgehog (Hh) signaling pathway with potential antineoplastic activity.
T16843	Saridegib	IPI-926,Patidegib	Others
	Saridegib is an effective and specific inhibitor of Smoothened and a key signaling transmembrane protein in the Hedgehog pathway.		Others
T75148	Hedgehog IN-3
	Hedgehog IN-3 (compound 3), with an IC50 value of 0.01 µM, serves as a hedgehog pathway inhibitor, proving beneficial for cancer research applications [1].
T79055	Hedgehog IN-2
	Hedgehog IN-2 (Compound 20) functions as an inhibitor of the Hedgehog signaling pathway, exhibiting an IC50 of <0.003 μM in C3H10T1/2 cells [1].
T71338	Patidegib HCl
	Patidegip, laos known as Saridegib and IPI-926, is an orally bioavailable, cyclopamine-derived (for structure comparison see Fig 1) inhibitor of the Hedgehog (Hh) pathway with potential antineoplastic activity. Specific...
T28388	PF-5274857 mseylate (1373615-35-0 free base)	PF5274857 HCl,PF 5274857,PF-5274857,PF-5274857 mesylate,PF-5274857 mseylate
	PF-5274857 is a potent, orally active and selective inhibitor of hedgehog (Hh) signaling pathway (IC50 = 5.8 nM, Ki = 4.6 nM) . PF-5274857 effectively penetrates the blood-brain barrier and inhibits Smo activity in the b...
T79907	HPP-9
	HPP-9, a Proteolysis-Targeting Chimera (PROTAC) derived from Hedgehog Pathway Inhibitor-1 (HPI-1) with a pIC50 value of 6.71, is designed to degrade BET bromodomains and exhibits antitumor activity [1].